![]() ![]() The application of optical coherence tomography angiography in cerebral small vessel disease, ischemic stroke, & dementia: a systematic review.Ģ4 Jul 20. Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects.ġ0 Sep 20. Studying blood vessels in the eye is also useful in detecting and understanding diseases that affect the human circulatory system such as high blood pressure, diabetes and heart disease.įor example, with further research, we may soon be able to identify people with undiagnosed high blood pressure through pictures of their retina, thus enabling a doctor to prescribe appropriate medication and considerably reduce their risk of having a future heart attack or stroke.Ģ3 Sep 20. Subtle changes in the retina may reflect similar processes happening and these early signs may precede declining brain health by years or even decades. We are researching how we can use information from images of the retina to understand what is happening in the brain. These anatomical structures are shared with the brain, but where they are much less accessible. The back of the eye is called the retina and is one of the few places in the human body allowing easy observation of blood vessels and nerves. However, we analyse these images in more detail to see what other information they could reveal about the health of human body and brain. Similar types of imaging are performed at a high street optician for a standard eye health check-up. Light reflected back leaves the same way to be collected by the machine creating an image of the retina. Recognizing the multimodal imaging features of SMD associated with BD, described in detail in this study, will guide practitioners to the accurate diagnosis of BD and reduce the risk of unnecessary intraocular procedures with potential complications.Light from very low-power lasers or a camera flash enters the eye through the pupil. The positive correlation of subfoveal choroidal thickness with age in BD patients may be a factor in the pathogenesis and development of SMD in this population. The diagnosis of BD should be considered in patients presenting with SMD and recalcitrant subretinal fluid masquerading as neovascular age-related macular degeneration or chronic central serous chorioretinopathy to avoid unnecessary treatment procedures. ![]() Choroidal neovascularization was identified in four eyes on optical coherence tomography angiography, but these eyes did not respond to anti-vascular endothelial growth factor treatment. Subfoveal choroidal thickness positively correlated with age for our cohort, increasing linearly at a rate of 25.6 µm per decade (R = 0.64 P < 0.001). Mean logarithm of the minimum angle of resolution best-corrected visual acuity for all 26 eyes at last follow-up was +0.36 (Snellen equivalent of 20/46). Best disease was subsequently diagnosed genetically in six patients and by detailed family history in seven. Nine patients presented with a history of SMD and subretinal fluid recalcitrant to various therapies, including intravitreal anti-vascular endothelial growth factor injections and photodynamic therapy. Twenty-six eyes of 13 patients (5 women) were included. Subfoveal choroidal thickness was also formally measured, and an age-related choroidal thickness analysis was performed and compared with a normal population. This study will also present data to support age-related progressive choroidal thickening in BD patients, which may play a role in the development of SMD in this population.Ĭlinical examination and multimodal imaging findings, including color fundus photography, spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and optical coherence tomography-angiography, were reviewed and analyzed. To describe the clinical and multimodal imaging findings of a series of cases of serous macular detachment (SMD) caused by Best disease (BD) masquerading as neovascular age-related macular degeneration or central serous chorioretinopathy that were inappropriately treated with intravitreal anti-vascular endothelial growth factor or laser therapy. ![]()
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